Tian Wu Selected Research

Hematologic Neoplasms (Hematological Malignancy)

1/2019	Discovery of ( R)-8-(6-Methyl-4-oxo-1,4,5,6-tetrahydropyrrolo[3,4- b]pyrrol-2-yl)-3-(1-methylcyclopropyl)-2-((1-methylcyclopropyl)amino)quinazolin-4(3 H)-one, a Potent and Selective Pim-1/2 Kinase Inhibitor for Hematological Malignancies.
1/2016	Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

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Tian Wu Research Topics

Disease

13	Neoplasms (Cancer) 12/2023 - 01/2011
6	Inflammation (Inflammations) 12/2022 - 04/2012
5	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 04/2012
4	Tuberculosis (Tuberculoses) 10/2023 - 01/2015
4	Hepatocellular Carcinoma (Hepatoma) 03/2021 - 10/2010
3	COVID-19 01/2024 - 01/2023
3	Infections 01/2023 - 08/2017
3	Non-alcoholic Fatty Liver Disease 01/2023 - 01/2021
3	Obesity 01/2022 - 02/2011
3	Insulin Resistance 01/2022 - 05/2014
2	Thrombosis (Thrombus) 04/2024 - 06/2013
2	Melanoma (Melanoma, Malignant) 04/2022 - 01/2019
2	Atrophy 03/2022 - 06/2016
2	Fatty Liver 01/2022 - 01/2021
2	Asthma (Bronchial Asthma) 01/2022 - 07/2015
2	Leukemia 01/2020 - 04/2016
2	Lymphoma (Lymphomas) 01/2020 - 04/2016
2	Hematologic Neoplasms (Hematological Malignancy) 01/2019 - 01/2016
2	Multiple Myeloma 04/2016 - 01/2016
2	Body Weight (Weight, Body) 08/2015 - 02/2011
2	Atherosclerosis 06/2013 - 04/2012
1	Breast Neoplasms (Breast Cancer) 05/2024
1	Atrial Fibrillation 05/2024
1	Vascular Calcification 05/2024
1	Hashimoto Disease (Thyroiditis, Hashimoto) 05/2024
1	Papillary Thyroid Cancer 05/2024
1	Splenomegaly 12/2023
1	Fever (Fevers) 12/2023
1	Cytopenia 12/2023
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 12/2023
1	Blister (Bulla) 11/2023
1	Hypertension (High Blood Pressure) 10/2023
1	Hyperglycemia 10/2023
1	Chronic Disease (Chronic Diseases) 10/2023
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 10/2023
1	Fibrosis (Cirrhosis) 07/2023
1	Diabetes Mellitus 07/2023
1	Wounds and Injuries (Trauma) 02/2023
1	Disease Resistance 02/2023
1	Hypoglycemia (Reactive Hypoglycemia) 01/2023
1	Gestational Diabetes (Gestational Diabetes Mellitus) 01/2023
1	Fetal Distress 01/2023

Drug/Important Bio-Agent (IBA)

6	Phosphotransferases (Kinase)IBA 07/2022 - 03/2011
3	Biomarkers (Surrogate Marker)IBA 05/2024 - 01/2019
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 10/2010
3	CD40 Ligand (CD40L)IBA 05/2014 - 04/2012
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 04/2024 - 01/2016
2	KinesinsIBA 12/2023 - 01/2022
2	Proteins (Proteins, Gene)FDA Link 12/2023 - 01/2022
2	Interleukin-6 (Interleukin 6)IBA 01/2023 - 08/2015
2	Ion Channels (Ion Channel)IBA 04/2022 - 01/2019
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2022 - 08/2015
2	Betaine (C.B.B.)FDA Link 10/2021 - 01/2021
2	LipidsIBA 10/2021 - 01/2021
2	Chlorodiphenyl (54% Chlorine)IBA 06/2016 - 08/2015
2	Polychlorinated Biphenyls (PCBs)IBA 06/2016 - 08/2015
2	Insulin (Novolin)FDA Link 08/2015 - 02/2011
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 11/2014 - 09/2012
2	tributyltinIBA 05/2014 - 02/2011
1	Catalytic DNA (Deoxyribozyme)IBA 05/2024
1	Dabigatran FDA Link 05/2024
1	RivaroxabanIBA 05/2024
1	Warfarin (Coumadin)FDA LinkGeneric 05/2024
1	AnticoagulantsIBA 05/2024
1	Thyroxine (Levothyroxine)FDA LinkGeneric 05/2024
1	TabletsIBA 05/2024
1	TicagrelorIBA 04/2024
1	dorzolamide (Trusopt)FDA LinkGeneric 01/2024
1	SarinIBA 01/2024
1	Benzo(a)pyreneIBA 01/2024
1	tetrandrineIBA 01/2024
1	QuercetinIBA 01/2024
1	periodate-oxidized adenosineIBA 01/2024
1	8-Bromo Cyclic Adenosine Monophosphate (8 Bromo Cyclic Adenosine Monophosphate)IBA 01/2024
1	Desipramine (Pertofrane)FDA LinkGeneric 01/2024
1	perfluorooctanoic acidIBA 01/2024
1	perfluoro-n-heptanoic acidIBA 01/2024
1	Transaminases (Aminotransferases)IBA 12/2023
1	pembrolizumabIBA 12/2023
1	Excipients (Suspending Agents)IBA 11/2023
1	PowdersIBA 11/2023
1	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 07/2023
1	suberinIBA 02/2023
1	Calcitriol (Calcijex)FDA LinkGeneric 01/2023
1	Ritodrine (Yutopar)FDA Link 01/2023
1	Palmitic Acid (Hexadecanoic Acid)IBA 01/2023
1	phorbolIBA 01/2023
1	LucanthoneIBA 01/2023
1	Oleic Acid (Oleate)IBA 01/2023
1	Progesterone FDA LinkGeneric 01/2023
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2023
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2023
1	Dexamethasone (Maxidex)FDA LinkGeneric 01/2023
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 01/2023

Therapy/Procedure

9	Therapeutics 05/2024 - 09/2012
1	Precision Medicine 05/2024
1	Thrombolytic Therapy 04/2024
1	Dry Powder Inhalers 11/2023
1	Contraindications 10/2023
1	Immunotherapy 10/2023